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Using in vivo imaging to understand the hypoxic immune response to TB
Welcome to our website!
We are fascinated by the immune cells of our body (white blood cells, specifically the macrophages and neutrophils) and want to understand their behaviours during bacterial disease so that we can improve how they work to help us clear deadly infections such as tuberculosis. |
We are especially interested in the regulation of hypoxia signalling during TB. The above image shows red labelled white blood cells (macrophages) with internalised bacteria and activated hypoxia signalling (white). The only way to understand this properly is to watch them in action in vivo... to do this we use a zebrafish model of TB. |
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Latest News and Opportunities
Zebrafish Infection UK 2018 We had great fun holding the Zebrafish Infection UK meeting (https://www.zebrafishinfection.co.uk/photos) in Sheffield yesterday with the Johnston Lab. It was a fantastic meeting with some great science on show. The JEEK Retreat 2017 With the Johnston, Evans and King labs we had our annual phagocyte "JEEK" retreat. There was lots of science, team building and lab-based fancy dress (we, of course, went as Elks!). |
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